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From what I understand the pole spacing on Strat pickups is a standard 52mm for all three - neck, middle, and bridge.
With a vintage spaced bridge however where the string spacing is 2 7/32” or 56.4mm, I find that the first and six strings lie outside the magnets for the bridge pickup - this is of course further exaggerated by the angle of the pickup, which effectively shortens the pickup relative to the strings. The middle and neck pickups are okay for string to pole piece alignment.
I find that this non-alignment is sufficient to make the 1st string significantly quieter. This is particularly evident in mild overdrive, when the 2nd and 3rd strings yield a nice saturated tone but the first string sounds clean - that's really weird.
It is not so evident why playing clean (and I use my Stratocaster only for clean sounds) so in practical terms it’s not really a problem.
I am curious though - apart from changing to a narrower spaced bridge is there a simple solution?