Good tweaks to the Yamaha THR?

Vinylfan

Hi
I've had my THR10 for a while now and have only used the default settings.  I tend to stay on the Clean and Crunch with occasional venturing into Lead.
I've messed about with the Chorus effect and delay and reverb too.
So the question is - are there some recommended settings in the editor to make it even better??  I thought it might be worth asking to see what people have experimented with and found useful to give me a starting point.
I'm not going to be going into the editor all the time so some set and forget tweaks would be good to hear about.
Thanks

Collings

Changing the speaker models for the lead and hi gain lead improves the tones available for me

DiscoStu

Yeah, changing the cabs for sure. 

bandmaster188

As above. I found the American 4x12 works well with the crunch and lead channels. Certainly gives things a fuller sound.