I just did a part trade of my Ceriatone OTS 20 watter for a Ampli-firebox. And this is my setup now.
Amplifirebox -> Focusrite 2i4 -> IK Multimedia iLoud micro monitors
It sounds so realistic (clean, crunch and lead!) and it is so much easier to record great tones to Ableton Live/Cubase if I want to do some recording. I didn't really need a nice big tube amp as I don't gig, and even if I have the occasional performance, I'd be able to go straight to PA with less faffing about.
I have tried to go direct to PA/audio interface before, having tried the Tech 21 blonde, Joyo American, Zoom G3, Amplitube. But they either sounded dull, digital or had bad latency (amplitube). This truly is in a league of its own!
I just hope I don't encounter issues with my unit like
@p90fool.