For me it's a four-piece consisting of singer, guitarist, bass, and drums.
I've just been reading Motherless Child (the Clapton biography) and have just got to the first Cream gigs and the bit detailing the dynamics of a three-piece setup is fascinating, partly because of the animosity between Baker and Bruce, but also due to the fact that everyone tended to 'overplay' and fill in the gaps.
I find being in a one-guitarist setup forces me to up my game a bit. But I like to think I don't overplay. I feel that any gaps aren't actually noticed by anyone listening. I just go for a touch more gain and a hint of reverb to help during the guitar fills but that's about it really.
I play guitar because I enjoy it rather than because I’m any good at it
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2x singers: Jeff Buckley & a resurrected Nina Simone
Guitar and keys: Jack White
Bass: Paul McCartney
Drums: John Densmore of the Doors
In my mind they'd perform really filthy jazzy bluesey stuff, with the high voice of Buckley harmonising with the lower tones of Simone, with awesome hypnotic drumming from Densmore
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2 guitars, bass, drums, singist, keys.
Provided the singist can play guitar/bass (or in rare cases drums) then a 4 piece.
Ringleader of the Cambridge cartel, pedal champ and king of the dirt boxes (down to 21)
Keys: JS Bach
Bass: GF Händel
Guitar: Antonio Vivaldi
Drums: Bill Bruford
To play in: A 4-piece with the above instrumentation, or, that plus saxes & brass. Keys to include Hammond, Rhodes & Grand Piano sounds. Not really bothered with vocals, it's wasted space between the music.
Seriously: If you value it, take/fetch it yourself