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In my opinion, no interface will "significantly improve the audio quality" in as much as it being a 'night and day' difference. When you get to preamps and converters (which is what the difference will be between interfaces) being used within their intended range of operation, it's VERY subtle differences.
*As far as I know you may already have!
So good that I don't even notice it.
I've had no end of grief with PCI cards after moving to W7 - that would be my only advice, avoid PCI cards !
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I've got the Focusrite 18i20 as my laptop/location interface and I really like it (Emu 1212m on my 'main' studio desktop - the Focusrite works as an ADAT expander for this as well, which is neat.) Haven't had any problems, but if it's a known problem with Dell computers, then you may well have to change.
Might want to try cheaper options first - if a desktop, get a new USB 2.0 / 3.0 card
A laptop - try a docking station
And don't use USB audio through a USB hub or port doubler.
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