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Does it show up as a device in Audio Midi setup?
Right, well if I was working for Focusrite tech support I would get you to connect first to a different USB port, then use a different cable and then finally to a different computer.
If it doesn't work in all three instances then it is DOA and you can insist in a replacement if you are buying new.
If it works on another computer then you have a Mac OSX issue.
You can start swapping out system files or, if you want a quicker resolution, just reinstall Mac OSX.
Why are you still on El Capitan?
Studio: https://www.voltperoctave.com
Music: https://www.euclideancircuits.com
Me: https://www.jamesrichmond.com
It ALWAYS shows up as Hardware in About this Mac>System Report
Just never got round to upgrading. Would that help?
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Telecaster American Deluxe, Cornell Romany amp, without the talent to use them properly
Backup the data, format the drive and reinstall the operating system and all apps, then restore the data.
If it still doesn't work you either have a hardware problem with the Mac, or there is a problem with the Focusrite.
Studio: https://www.voltperoctave.com
Music: https://www.euclideancircuits.com
Me: https://www.jamesrichmond.com
OSX 10.11.6 El Capitan was current between September 2015 and September 2016. The Focusrite OS Compatibility Guide says that the OP's combination of gear should work.
A couple of revisions ago, OSX went completely over to 64-bit. Earlier 32-bit audio applications are often ignored.